USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: GBB3_HUMAN USC-OGP 2-DE database:  GBB3_HUMAN GBB3_HUMAN General information about the entry View entry in simple text format Entry name GBB3_HUMAN Primary accession number P16520 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; AltName: Full=Transducin beta chain 3;. Gene name Name=GNB3 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0459: pI=5.23; Mw=34396 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0738: pI=5.21; Mw=35517 SPOT OGP-0743: pI=5.23; Mw=34991 Cross-references UniProtKB/Swiss-Prot P16520; GBB3_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GBB3_HUMAN Primary accession number P16520 Secondary accession number(s) Q96B71 Q9BQC0 Sequence was last modified on  August 1, 1990 (version 1) Annotations were last modified on  March 15, 2017 (version 181) Name and origin of the protein Description RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; AltName: Full=Transducin beta chain 3; Gene name Name=GNB3 Encoded on Name=GNB3 Keywords Alternative splicing; Complete proteome; Congenital stationary night blindness; Direct protein sequencing; Disease mutation; Polymorphism; Reference proteome; Repeat; Transducer; WD repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M31328; AAA52582.1; -; mRNA EMBL U47924; AAB51313.1; -; Genomic_DNA EMBL U47930; AAC50468.1; -; mRNA EMBL Y12050; CAA72779.1; -; Genomic_DNA EMBL Y12051; CAA72779.1; JOINED; Genomic_DNA EMBL Y12052; CAA72779.1; JOINED; Genomic_DNA EMBL Y12053; CAA72779.1; JOINED; Genomic_DNA EMBL Y12054; CAA72779.1; JOINED; Genomic_DNA EMBL Y12055; CAA72779.1; JOINED; Genomic_DNA EMBL Y12056; CAA72779.1; JOINED; Genomic_DNA EMBL Y12057; CAA72779.1; JOINED; Genomic_DNA EMBL Y12058; CAA72779.1; JOINED; Genomic_DNA EMBL AF501884; AAM15920.1; -; mRNA EMBL BT009800; AAP88802.1; -; mRNA EMBL AY631872; AAT38116.1; -; Genomic_DNA EMBL BC000115; AAH00115.1; -; mRNA EMBL BC002454; AAH02454.1; -; mRNA EMBL BC015920; AAH15920.1; -; mRNA CCDS CCDS8564.1; -. [P16520-1]; . PIR A35096; RGHUB3; . RefSeq NP_001284500.1; NM_001297571.1; . RefSeq NP_002066.1; NM_002075.3. [P16520-1]; . UniGene Hs.631657; -; . ProteinModelPortal P16520; -; . SMR P16520; -; . BioGrid 109046; 29; . DIP DIP-601N; -; . IntAct P16520; 6; . MINT MINT-2801250; -; . STRING 9606.ENSP00000229264; -; . iPTMnet P16520; -; . PhosphoSitePlus P16520; -; . SwissPalm P16520; -; . BioMuta GNB3; -; . DMDM 121011; -; . OGP P16520; -; . MaxQB P16520; -; . PaxDb P16520; -; . PeptideAtlas P16520; -; . PRIDE P16520; -; . DNASU 2784; -; . Ensembl ENST00000229264; ENSP00000229264; ENSG00000111664. [P16520-1]; . GeneID 2784; -; . KEGG hsa:2784; -; . UCSC uc001qrd.3; human. [P16520-1]; . CTD 2784; -; . DisGeNET 2784; -; . GeneCards GNB3; -; . HGNC HGNC:4400; GNB3; . HPA HPA040736; -; . MalaCards GNB3; -; . MIM 139130; gene; . MIM 617024; phenotype; . neXtProt NX_P16520; -; . OpenTargets ENSG00000111664; -; . PharmGKB PA176; -; . eggNOG KOG0286; Eukaryota; . eggNOG ENOG410XQUX; LUCA; . GeneTree ENSGT00760000119239; -; . HOGENOM HOG000176356; -; . HOVERGEN HBG000188; -; . InParanoid P16520; -; . KO K07825; -; . OMA YAHESII; -; . OrthoDB EOG091G0A7T; -; . PhylomeDB P16520; -; . TreeFam TF106149; -; . Reactome R-HSA-1296041; Activation of G protein gated Potassium channels; . Reactome R-HSA-163359; Glucagon signaling in metabolic regulation; . Reactome R-HSA-202040; G-protein activation; . Reactome R-HSA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; . Reactome R-HSA-381771; Synthesis; secretion; and inactivation of Glucagon-like Peptide-1 (GLP-1) Reactome R-HSA-392170; ADP signalling through P2Y purinoceptor 12; . Reactome R-HSA-392451; G beta:gamma signalling through PI3Kgamma; . Reactome R-HSA-392851; Prostacyclin signalling through prostacyclin receptor; . Reactome R-HSA-400042; Adrenaline; noradrenaline inhibits insulin secretion; . Reactome R-HSA-4086398; Ca2+ pathway; . Reactome R-HSA-416476; G alpha (q) signalling events; . Reactome R-HSA-416482; G alpha (12/13) signalling events; . Reactome R-HSA-418217; G beta:gamma signalling through PLC beta; . Reactome R-HSA-418555; G alpha (s) signalling events; . Reactome R-HSA-418592; ADP signalling through P2Y purinoceptor 1; . Reactome R-HSA-418594; G alpha (i) signalling events; . Reactome R-HSA-418597; G alpha (z) signalling events; . Reactome R-HSA-420092; Glucagon-type ligand receptors; . Reactome R-HSA-428930; Thromboxane signalling through TP receptor; . Reactome R-HSA-432040; Vasopressin regulates renal water homeostasis via Aquaporins; . Reactome R-HSA-456926; Thrombin signalling through proteinase activated receptors (PARs); . Reactome R-HSA-500657; Presynaptic function of Kainate receptors; . Reactome R-HSA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; . Reactome R-HSA-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; . SignaLink P16520; -; . SIGNOR P16520; -; . ChiTaRS GNB3; human; . GeneWiki GNB3; -; . GenomeRNAi 2784; -; . PRO PR:P16520; -; . Proteomes UP000005640; Chromosome 12; . Bgee ENSG00000111664; -; . CleanEx HS_GNB3; -; . ExpressionAtlas P16520; baseline and differential; . Genevisible P16520; HS; . GO GO:0044297; C:cell body; IEA:Ensembl; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0030425; C:dendrite; IEA:Ensembl; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0003924; F:GTPase activity; TAS:ProtInc; . GO GO:0051020; F:GTPase binding; IPI:UniProtKB; . GO GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW; . GO GO:0071377; P:cellular response to glucagon stimulus; TAS:Reactome; . GO GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc; . GO GO:0006457; P:protein folding; TAS:Reactome; . GO GO:0008217; P:regulation of blood pressure; TAS:ProtInc; . Gene3D 2.130.10.10; -; 1; . InterPro IPR020472; G-protein_beta_WD-40_rep; . InterPro IPR001632; Gprotein_B; . InterPro IPR016346; Guanine_nucleotide-bd_bsu; . InterPro IPR015943; WD40/YVTN_repeat-like_dom; . InterPro IPR001680; WD40_repeat; . InterPro IPR019775; WD40_repeat_CS; . InterPro IPR017986; WD40_repeat_dom; . PANTHER PTHR19850; PTHR19850; 1; . Pfam PF00400; WD40; 7; . PRINTS PR00319; GPROTEINB; . PRINTS PR00320; GPROTEINBRPT; . SMART SM00320; WD40; 7; . SUPFAM SSF50978; SSF50978; 1; . PROSITE PS00678; WD_REPEATS_1; 3; . PROSITE PS50082; WD_REPEATS_2; 5; . PROSITE PS50294; WD_REPEATS_REGION; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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